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Perforación cardiaca asociada a cirugía de reemplazo valvular mitral
Quirós Alpízar,José Luis; Miranda Solís,Lisa; Sevilla Acosta,Fabricio José;
Revista Costarricense de Cardiología , 2011,
Abstract: a 55 years old female patient with a history of epilepsy, was admitted for elective cardiac surgery. mitral valve replacement was performed with bioprosthesis, the surgery was complicated by a left ventricular laceration that ultimately resulted in the death of the patient during the postoperative period. the autopsy findings are presented
Perforación cardiaca asociada a cirugía de reemplazo valvular mitral
José Luis Quirós Alpízar,Lisa Miranda Solís,Fabricio José Sevilla Acosta
Revista Costarricense de Cardiología , 2011,
Abstract: Se presenta el caso de una mujer de 55 a os de edad, con antecedente de epilepsia, que ingresa para cirugía electiva de reemplazo valvular. Se realizó reemplazo de la válvula mitral con una prótesis biológica, el cual se complicó con una laceración del ventrículo izquierdo, motivo por el que la paciente falleció en el período post- operatorio. Se presentan los hallazgos de la autopsia A 55 years old female patient with a history of epilepsy, was admitted for elective cardiac surgery. Mitral valve replacement was performed with bioprosthesis, The surgery was complicated by a left ventricular laceration that ultimately resulted in the death of the patient during the postoperative period. The autopsy findings are presented
Keratinocyte-Targeted Overexpression of the Glucocorticoid Receptor Delays Cutaneous Wound Healing
Ana Sanchis, Lorena Alba, Víctor Latorre, Lisa M. Sevilla, Paloma Pérez
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029701
Abstract: Delayed wound healing is one of the most common secondary adverse effects associated to the therapeutic use of glucocorticoid (GC) analogs, which act through the ligand-dependent transcription factor GC-receptor (GR). GR function is exerted through DNA-binding-dependent and –independent mechanisms, classically referred to as transactivation (TA) and transrepression (TR). Currently both TA and TR are thought to contribute to the therapeutical effects mediated by GR; however their relative contribution to unwanted side effects such as delayed wound healing is unknown. We evaluated skin wound healing in transgenic mice with keratinocyte-restricted expression of either wild type GR or a mutant GR that is TA-defective but efficient in TR (K5-GR and K5-GR-TR mice, respectively). Our data show that at days (d) 4 and 8 following wounding, healing in K5-GR mice was delayed relative to WT, with reduced recruitment of granulocytes and macrophages and diminished TNF-α and IL-1β expression. TGF-β1 and Kgf expression was repressed in K5-GR skin whereas TGF-β3 was up-regulated. The re-epithelialization rate was reduced in K5-GR relative to WT, as was formation of granulation tissue. In contrast, K5-GR-TR mice showed delays in healing at d4 but re-established the skin breach at d8 concomitant with decreased repression of pro-inflammatory cytokines and growth factors relative to K5-GR mice. Keratinocytes from both transgenic mice closed in vitro wounds slower relative to WT, consistent with the in vivo defects in cell migration. Overall, the delay in the early stages of wound healing in both transgenic models is similar to that elicited by systemic treatment with dexamethasone. Wound responses in the transgenic keratinocytes correlated with reduced ERK activity both in vivo and in vitro. We conclude that the TR function of GR is sufficient for negatively regulating early stages of wound closure, while TA by GR is required for delaying later stages of healing.
Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation
Elena Carceller,Judit Bigas,Julia Boix,Lisa M. Sevilla,Paloma Pérez
- , 2018, DOI: 10.1038/s41419-018-0673-z
Abstract: a Hematoxylin & eosin (H&E)-stainings (top) and loricrin and keratin(K)6 immunohistochemistry (middle, bottom) of skin sections from postnatal day (P) 0. Control (CO), GR epidermal knockout (GREKO), MR epidermal knockout (MREKO) or combined GR and MR epidermal knockout (DKO). Dotted line separates epidermis and dermis. Arrows: defective differentiation and minimal stratum corneum; hash: altered stratum corneum. b H&E-stained sections of CO and DKO mouse skin at the indicated postnatal days (P1, P3). Asterisks: microabscesses. c Immunostaining for Ly6G, phospho(p)-p38, and p-ERK of mouse skin from CO, DKO, GREKO, and MREKO P1 littermates. Asterisks: neutrophil-containing microabscesses. d Gene expression was quantitated by RT-QPCR using epidermal RNA from P0 DKO, GREKO, and MREKO mice (relative to CO). Asterisks indicate significant differences relative to CO and hashes significant differences between DKO and single KO: *, #？<？0.05, **？<？0.01, ***, ###？<？0.001; n？>？3 in each experimental grou
Justification of public investment initiatives on water transfer systems as an instrument for water balances in Spain: the case of the Júcar–Vinalopó water transfer system  [PDF]
Martin Sevilla, Teresa Torregrosa
Agricultural Sciences (AS) , 2011, DOI: 10.4236/as.2011.24067
Abstract: One of the most controversial issues in recent years in water management has been finding a balance between available resources and water needs related to certain territories. The changes brought about by a new awareness over the need to preserve the environment, the social perception of the ownership of the river channels, the need for adjust financial costs arising from the waterworks and the compliance with European standards urgently require redesign of water supply policies in force at this time. The Júcar-Vinalopó water transfer, considered as an historic aspiration for many years in the region, has been regarded as a key element for solving the depletion of groundwater in a large area located in the southeast of the Iberian Peninsula, mainly for irrigation purposes. In this paper we present an approach to the economic aspects related to the implementation of the project, its investment and financing arrangements and the question of the subsequent management with the impact of the well-known “recovery cost principle", highlighting the current difficulties in carrying out projects of this size, due to severe limitations, as social and economic conditions of the transfer.
El trabajo nocturno y sus implicaciones en la salud de médicos, enfermeras y oficiales de seguridad de los hospitales de la Caja Costaricense del Seguro Social en Costa Rica
Ana Imelda Barahona Madrigal,Ernesto José Vidaurre Mora,Fabricio José Sevilla Acosta,Jonathan Rodríguez Rodríguez
Medicina Legal de Costa Rica , 2013,
Abstract: En el presente trabajo se analiza la jornada laboral nocturna y las implicaciones que ésta tiene en la salud de los trabajadores de una institución que por sus características requiere atención las 24 horas, los siete días a la semana, como lo es la Caja Costarricense del Seguro Social. Para ello se escogió una muestra de médicos, enfermeras y oficiales de seguridad y se les interrogó acerca de las enfermedades que padecían, para tratar de establecer su relación con la jornada nocturna. This paper analyzes the night work and its implications on the health of workers in an institution which by its nature requires 24-hour care, seven days a week, as is La Caja Costarricense de Seguro Social. For this, it was chosen a sample of doctors, nurses and security officers and they were questioned about illnesses they had, to try to establish its relationship with the night shift.
"NO VENGO A PEDIRTE NADA": LA MúSICA EN VILLA RICA, CAUCA, COMO UN ESPACIO DONDE SE HACE SOCIEDAD
SEVILLA,MANUEL;
Revista Colombiana de Antropología , 2009,
Abstract: this paper presents the results from a recent research about traditional music practices at villa rica, cauca, colombia. from an ethnographic description of three social contexts (the nativity celebration, children and adults wake, and work and leisure spaces), and a exploration of different ways to deal with demands of physical and human work resources, the article argues that traditional music practices are privileged instances where people communicate, transform and reassert the different criteria of collective action. criteria that are at the basis of solidarity practices of villa rica villagers. in this sense, the main argument agrees with the idea that traditional music practices are spaces where society is made, and not just a reflection of it
Las músicas tradicionales como instancias de producción cultural: el caso de Villa Rica (Cauca)
SEVILLA,MANUEL;
Signo y Pensamiento , 2009,
Abstract: in this article we present the results of research work on the role played by folk music in the municipality of villa rica (cauca, colombia). thus, we describe three different social contexts (during the christmas celebrations of nativity, during children and adults' wakes, and both at the workplace and/or during recreational activities) where folk music is performed, plus two entrepreneurial projects related to music performance in the aforementioned contexts. based on pierre bourdieu's theories on cultural production, our text basically argues that there are intermediate zones where the "logics" common to the two different sub-fields merge together via the social agents involved in the activities
Marx(ismos) y las teorías de la justicia
Carlos Sevilla
Foro Interno : Anuario de Teoría Política , 2006,
Abstract: This article examines certain marxist critiques of the theories of justice that arose after the publication of A Theory of Justice, by John Rawls, in 1971. This book led the field of liberal political theory towards an explicitly normative focus that tended to develop into general theories or in systematic analyses of more specific concepts. In this article we shall broaden the sociological and historical critique of theories of justice based on the debate that began in the pages of the New Left Review.
El baile y la cultura global
Amparo Sevilla
Nueva antropología , 2000,
Abstract:
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